Article
Molecular screening and association study of IL15 gene polymorphisms in rheumatoid arthritis.
Cytokine - 1 May 2007
Rueda Blanca, López-Nevot Miguel A, González-Gay Miguel A, Balsa Alejandro, Pascual-Salcedo Dora, Garcia Antonio, Gonzalez Antonio, Martin Javier
Abstract excerpt
Interleukin 15 (IL-15) is a pleiotropic pro-inflammatory cytokine known to play a relevant role in rheumatoid arthritis (RA) pathogenesis. In this study we aimed to investigate for the first time the contribution of IL15 gene to RA susceptibility. We screened 13 single nucleotide polymorphisms (SNPs) localised within IL15 regulatory regions (promoter, 5' UTR region and 3' UTR region) in a total of 420...
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