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A Murine Database of Structural Variants Identifies A Candidate Gene for a Spontaneous Murine Lymphoma Model.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Mar 2026

Ren Wenlong, Fang Zhuoqing, Dolzhenko Egor, Saunders Christopher T, Cheng Zhuanfen, Popic Victoria, Peltz Gary

Abstract excerpt

A more complete map of the pattern of genetic variation among inbred mouse strains is essential for characterizing the genetic architecture of the many available mouse genetic models of important biomedical traits. Although structural variants (SVs) are a major component of genetic variation, they have not been adequately characterized among inbred strains due to methodological limitations. To address this, we...

Topics

Animals
Mice
Lymphoma
Disease Models, Animal
Genetic Predisposition to Disease
Mice, Inbred Strains
Databases, Genetic
Genetic Variation
Polymorphism, Single Nucleotide
Genomic Structural Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41604583
DOI: 10.1002/advs.202522890
PMCID: PMC13042391

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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