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Fibrinogen residue γAla341 is necessary for calcium binding and 'A-a' interactions.

Thrombosis and haemostasis - 1 May 2012

Park Rojin, Ping Lifang, Song Jaewoo, Hong Sung-Yu, Choi Tae-Youn, Choi Jong-Rak, Gorkun Oleg V, Lord Susan T

Abstract excerpt

The fibrinogen γ-module has several important sites relating to fibrinogen function, which include the high affinity calcium binding site, hole 'a' that binds with knob 'A', and the D:D interface. Residue γAla341, which is located in the vicinity of these sites, is altered in three variant fibrinogens: fibrinogen Seoul (γAla341Asp), Tolaga Bay (γAla341Val), and Lyon III (γAla341Thr). In order to investigate the...

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PMID: 22437918
DOI: 10.1160/TH11-10-0731

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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