Normal binding of calcium to five fibrinogen variants with mutations in the carboxy terminal part of the gamma-chain.

Article

Normal binding of calcium to five fibrinogen variants with mutations in the carboxy terminal part of the gamma-chain.

Thrombosis and haemostasis - 1 Sept 1996

Furlan M, Stucki B, Steinmann C, Jungo M, Lämmle B

Abstract excerpt

Calcium ions are known to accelerate polymerization of fibrin monomers. Each of the two carboxy terminal domains of normal fibrinogen contains one high-affinity calcium binding site that seems to be situated close to the polymerization site in the gamma-chain. Most hitherto described functionally...

Topics

Amino Acid Sequence
Binding Sites
Blood Coagulation
Calcium
Carboxylic Acids
Fibrinogen
Humans
Molecular Sequence Data
Mutation

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