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Article

Normal binding of calcium to five fibrinogen variants with mutations in the carboxy terminal part of the gamma-chain.

Thrombosis and haemostasis - 1 Sept 1996

Furlan M, Stucki B, Steinmann C, Jungo M, Lämmle B

Abstract excerpt

Calcium ions are known to accelerate polymerization of fibrin monomers. Each of the two carboxy terminal domains of normal fibrinogen contains one high-affinity calcium binding site that seems to be situated close to the polymerization site in the gamma-chain. Most hitherto described functionally defective fibrinogen variants showed impaired clot formation. Since the tightly bound calcium ions may influence the...

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Identifiers

PMID: 8883274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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