Article
Analysis of engineered fibrinogen variants suggests that an additional site mediates platelet aggregation and that "B-b" interactions have a role in protofibril formation.
Biochemistry - 23 Apr 2002
Lounes Karim C, Ping Lifang, Gorkun Oleg V, Lord Susan T
Abstract excerpt
The C-terminal domain of the fibrinogen gamma-chain includes multiple functional sites that have been defined in high-resolution structures and biochemical assays. Calcium binds to this domain through the side chains of gammaD318 and gammaD320 and the backbone carbonyls of gammaF322 and gammaG324. We have examined variant fibrinogens with alanine at position gamma318 and/or gamma320 and found that calcium...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.