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Article

A new substitution, gamma 358 Ser-->Cys, in fibrinogen Milano VII causes defective fibrin polymerization.

Blood - 15 Sept 1994

Steinmann C, Bögli C, Jungo M, Lämmle B, Heinemann G, Wermuth B, Redaelli R, Baudo F, Furlan M

Abstract excerpt

Fibrinogen Milano VII is a hereditary fibrinogen variant detected in a woman with no clinical symptoms of bleeding or thrombosis. Thrombin and reptilase clotting times were prolonged in six family members from three generations. Release of fibrinopeptides A and B was normal. Fibrin polymerization...

Topics

Adult
Albumins
Base Sequence
Cysteine
Electrophoresis, Polyacrylamide Gel
Female
Fibrin
Fibrinogens, Abnormal
Humans
Immunoblotting
Kinetics
Male
Mercaptoethanol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Pedigree

Polymerase Chain Reaction

Polymers

Source

Identifiers

PMID: 8080993

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8080993-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

A new substitution, gamma 358 Ser-->Cys, in fibrinogen Milano VII causes defective fibrin polymerization.PMID 8080993Read ↗

Fibrinogen Bern I: substitution gamma 337 Asn-->Lys is responsible for defective fibrin monomer polymerization.Semantic proximity Read ↗

Fibrinogen Milano XIII (Aalpha 19 Arg-->Gly): a dysfunctional variant with an amino acid substitution in the N-terminal polymerization site.Semantic proximity Read ↗

Defective fibrinogen polymerization associated with a novel gamma279Ala-->Asp mutation.Semantic proximity Read ↗

Fibrinogen Baltimore I: polymerization defect associated with a gamma 292Gly----Val (GGC----GTC) mutation.Semantic proximity Read ↗

Fibrinogen Hillsborough: a novel gammaGly309Asp dysfibrinogen with impaired clotting.Semantic proximity Read ↗

Fibrinogen anomalies and disease. A clinical update.Semantic proximity Read ↗

Fibrinogen Milano XII: a dysfunctional variant containing 2 amino acid substitutions, Aalpha R16C and gamma G165R.Semantic proximity Read ↗

Fibrinogen Alès: a homozygous case of dysfibrinogenemia (gamma-Asp(330)-->Val) characterized by a defective fibrin polymerization site "a".Semantic proximity Read ↗

New molecular defects in the gamma subdomain of fibrinogen D-domain in four cases of (hypo)dysfibrinogenemia: fibrinogen variants Hannover VI, Homburg VII, Stuttgart and Suhl.Semantic proximity Read ↗

Fibrinogen Krakow: a novel hypo/dysfibrinogenemia mutation in fibrinogen gamma chain (Asn325Ile) affecting fibrin clot structure and function.Semantic proximity Read ↗

A frameshift mutation in Exon V of the A alpha-chain gene leading to truncated A alpha-chains in the homozygous dysfibrinogen Milano IIISemantic proximity Read ↗

Polymerization defect of fibrinogen Baltimore III due to a gamma Asn308----Ile mutation.Semantic proximity Read ↗

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