Article
A congenitally abnormal fibrinogen (Vlissingen) with a 6-base deletion in the gamma-chain gene, causing defective calcium binding and impaired fibrin polymerization.
The Journal of biological chemistry - 15 Jul 1991
Koopman J, Haverkate F, Briët E, Lord S T
Abstract excerpt
A congenitally abnormal fibrinogen (Vlissingen) was isolated from the blood of a young woman suffering from massive pulmonary embolism. Fibrinogen Vlissingen showed an abnormal clotting time with both thrombin and Reptilase. The release of the fibrino-peptides A and B by thrombin was normal, but...
Topics
- Adult
- Base Sequence
- Calcium
- Chromosome Deletion
- Fibrin
- Fibrinogen
- Fibrinogens, Abnormal
- Gene Amplification
- Humans
- Kinetics
- Macromolecular Substances
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes