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Article

Claudin 18 is a novel negative regulator of bone resorption and osteoclast differentiation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 2012

Linares Gabriel R, Brommage Robert, Powell David R, Xing Weirong, Chen Shin-Tai, Alshbool Fatima Z, Lau K-H William, Wergedal Jon E, Mohan Subburaman

Abstract excerpt

Claudin 18 (Cldn-18) belongs to a large family of transmembrane proteins that are important components of tight junction strands. Although several claudin members are expressed in bone, the functional role for any claudin member in bone is unknown. Here we demonstrate that disruption of Cldn-18 in mice markedly decreased total body bone mineral density, trabecular bone volume, and cortical thickness in...

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Identifiers

PMID: 22437732
DOI: 10.1002/jbmr.1600
PMCID: PMC3377820

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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