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The Rac1 exchange factor Dock5 is essential for bone resorption by osteoclasts

4 Nov 2010

Abstract excerpt

Osteoporosis, which results from excessive bone resorption by osteoclasts, is the major cause of morbidity for elder people. Identification of clinically relevant regulators is needed to develop novel therapeutic strategies. Rho GTPases have essential functions in osteoclasts by regulating actin dynamics. This is of particular importance because actin cytoskeleton is essential to generate the sealing zone, an...

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PMID: 21542010
DOI: 10.1002/jbmr.282

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