Article
Genetic polymorphisms of 3'-untranslated region of SULT1A1 and their impact on tamoxifen metabolism and efficacy.
Breast cancer research and treatment - 1 Nov 2018
Sanchez-Spitman A B, Dezentjé V O, Swen J J, Moes D J A R, Gelderblom H, Guchelaar Henk-Jan
Abstract excerpt
PURPOSE: Tamoxifen has a wide inter-variability. Recently, two SNPs in the 3'-untranslated region (UTR) of the SULT1A1 gene, rs6839 and rs1042157, have been associated with decreased SULT1A1 activity. The aim of this study is to investigate the role of the rs6839 and rs1042157 on tamoxifen metabolism and relapse-free survival (RFS) in women diagnosed with early-breast cancer receiving tamoxifen. METHODS: Samples...