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Article

Impact of Human SULT1E1 Polymorphisms on the Sulfation of 17β-Estradiol, 4-Hydroxytamoxifen, and Diethylstilbestrol by SULT1E1 Allozymes.

European journal of drug metabolism and pharmacokinetics - 1 Jan 2021

El Daibani Amal A, Alherz Fatemah A, Abunnaja Maryam S, Bairam Ahsan F, Rasool Mohammed I, Kurogi Katsuhisa, Liu Ming-Cheh

Abstract excerpt

BACKGROUND AND OBJECTIVES: Previous studies have revealed that sulfation, as mediated by the estrogen-sulfating cytosolic sulfotransferase (SULT) SULT1E1, is involved in the metabolism of 17β-estradiol (E2), 4-hydroxytamoxifen (4OH-tamoxifen), and diethylstilbestrol in humans. It is an interesting question whether the genetic polymorphisms of SULT1E1, the gene that encodes the SULT1E1 enzyme, may impact on the...

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PMID: 33064293
DOI: 10.1007/s13318-020-00653-1
PMCID: PMC7855807

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