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Article

Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of acetaminophen and opioid drugs by the cytosolic sulfotransferase SULT1A3.

Archives of biochemistry and biophysics - 15 Jun 2018

Bairam Ahsan F, Rasool Mohammed I, Alherz Fatemah A, Abunnaja Maryam S, El Daibani Amal A, Kurogi Katsuhisa, Liu Ming-Cheh

Abstract excerpt

Sulfoconjugation has been shown to be critically involved in the metabolism of acetaminophen (APAP), morphine, tapentadol and O-desmethyl tramadol (O-DMT). The objective of this study was to investigate the effects of single nucleotide polymorphisms (SNPs) of human SULT1A3 and SULT1A4 genes on the sulfating activity of SULT1A3 allozymes toward these analgesic compounds. Twelve non-synonymous coding SNPs (cSNPs)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29705271
DOI: 10.1016/j.abb.2018.04.019
PMCID: PMC5969526

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