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Article

Generation and nuclear translocation of sumoylated transmembrane fragment of cell adhesion molecule L1.

The Journal of biological chemistry - 18 May 2012

Lutz David, Wolters-Eisfeld Gerrit, Joshi Gunjan, Djogo Nevena, Jakovcevski Igor, Schachner Melitta, Kleene Ralf

Abstract excerpt

The functions of the cell adhesion molecule L1 in the developing and adult nervous system are triggered by homophilic and heterophilic interactions that stimulate signal transductions that activate cellular responses. Here, we show that stimulation of signaling by function-triggering L1 antibodies or L1-Fc leads to serine protease-dependent cleavage of full-length L1 at the plasma membrane and generation of a...

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Identifiers

PMID: 22431726
DOI: 10.1074/jbc.M112.346759
PMCID: PMC3366775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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