Article
Mutations in the cell adhesion molecule L1 cause mental retardation.
Trends in neurosciences - 1 Apr 1995
Wong E V, Kenwrick S, Willems P, Lemmon V
Abstract excerpt
Recently, studies in the usually disparate fields of human genetics and developmental neurobiology have converged to reveal that some types of human mental retardation and brain malformations are due to mutations that affect the neural cell adhesion molecule L1. L1 has a very complex biology, interacting with a variety of ligands, and functioning in migration of neurons and growth of axons. Over the past few...
Topics
- Cell Adhesion Molecules
- Humans
- Intellectual Disability
- Mutation
- Structure-Activity Relationship