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Article

Single Nucleotide Polymorphism in Cell Adhesion Molecule L1 Affects Learning and Memory in a Mouse Model of Traumatic Brain Injury.

International journal of molecular sciences - 6 Mar 2024

Jiang Haoyu, Giarratana Anna O, Theis Thomas, Nagaraj Vini, Zhou Xiaofeng, Thakker-Varia Smita, Schachner Melitta, Alder Janet

Abstract excerpt

The L1 cell adhesion molecule (L1) has demonstrated a range of beneficial effects in animal models of spinal cord injury, neurodegenerative disease, and ischemia; however, the role of L1 in TBI has not been fully examined. Mutations in the L1 gene affecting the extracellular domain of this type 1 transmembrane glycoprotein have been identified in patients with L1 syndrome. These patients suffer from...

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Identifiers

PMID: 38474289
DOI: 10.3390/ijms25053043
PMCID: PMC10932301

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