Article
A Fragment of Adhesion Molecule L1 Binds to Nuclear Receptors to Regulate Synaptic Plasticity and Motor Coordination.
Molecular neurobiology - 1 Sept 2018
Kraus Kristina, Kleene Ralf, Henis Melad, Braren Ingke, Kataria Hardeep, Sharaf Ahmed, Loers Gabriele, Schachner Melitta, Lutz David
Abstract excerpt
Proteolytic cleavage of the neuronal isoform of the murine cell adhesion molecule L1, triggered by stimulation of the cognate L1-dependent signaling pathways, results in the generation and nuclear import of an L1 fragment that contains the intracellular domain, the transmembrane domain, and part of the extracellular domain. Here, we show that the LXXLL and FXXLF motifs in the extracellular and transmembrane...
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