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Article

Cis and trans interactions of L1 with neuropilin-1 control axonal responses to semaphorin 3A.

The EMBO journal - 2 Dec 2002

Castellani V, De Angelis E, Kenwrick S, Rougon G

Abstract excerpt

Mutations in the L1 gene induce a spectrum of human neurological disorders due to abnormal development of several brain structures and fiber tracts. Among its binding partners, L1 immunoglobulin superfamily adhesion molecule (Ig CAM) associates with neuropilin-1 (NP-1) to form a semaphorin3A (Sema3A) receptor and soluble L1 converts Sema3A-induced axonal repulsion into attraction. Using L1 constructs containing...

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Identifiers

PMID: 12456642
DOI: 10.1093/emboj/cdf645
PMCID: PMC136949

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Source receipt: pubmed, retrieved 7 Sept 2026.

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