Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inherent mosaicism and extensive mutation of human placentas.

Nature - 1 Apr 2021

Coorens Tim H H, Oliver Thomas R W, Sanghvi Rashesh, Sovio Ulla, Cook Emma, Vento-Tormo Roser, Haniffa Muzlifah, Young Matthew D, Rahbari Raheleh, Sebire Neil, Campbell Peter J, Charnock-Jones D Stephen, Smith Gordon C S, Behjati Sam

Abstract excerpt

Placentas can exhibit chromosomal aberrations that are absent from the fetus1. The basis of this genetic segregation, which is known as confined placental mosaicism, remains unknown. Here we investigated the phylogeny of human placental cells as reconstructed from somatic mutations, using whole-genome sequencing of 86 bulk placental samples (with a median weight of 28 mg) and of 106 microdissections of placental...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biopsy
Share to Mesoderm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mosaicism

Share to Mutation Rate

Share to Placenta

Share to Trisomy

Share to Trophoblasts

Share to Zygote

Source

Open in PubMed Open full text

Identifiers

PMID: 33692543
DOI: 10.1038/s41586-021-03345-1
PMCID: PMC7611644

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inherent mosaicism and extensive mutation of human placentas.PMID 33692543Read ↗

Somatic mutations reveal widespread mosaicism and mutagenesis in human placentasSemantic proximity Read ↗

Deep genome sequencing reveals extensive genetic heterogeneity in early human placentasSemantic proximity Read ↗

Deep Genome Sequencing Uncovers Extensive Genetic Heterogeneity in Early Human PlacentasSemantic proximity Read ↗

Placental somatic mutation in human stillbirth and live birth: A pilot case-control study of paired placental, fetal, and maternal whole genomes.Semantic proximity Read ↗

Extensive load of somatic CNVs in the human placentaSemantic proximity Read ↗

Advances in single-cell DNA sequencing enable insights into human somatic mosaicism.Semantic proximity Read ↗

Extensive phylogenies of human development inferred from somatic mutations.Semantic proximity Read ↗

Somatic mosaicism: implications for disease and transmission genetics.Semantic proximity Read ↗

Patterns of mosaicism for sequence and copy-number variants discovered through clinical deep sequencing of disease-related genes in one million individuals.Semantic proximity Read ↗

Distinctive aspects of the placental epigenome and theories as to how they ariseSemantic proximity Read ↗

Copy Number Variation Is a Fundamental Aspect of the Placental GenomeSemantic proximity Read ↗

Human embryonic genetic mosaicism and its effects on development and disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.