Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Monoallelic and biallelic deletions of 13q14.3 in chronic lymphocytic leukemia: FISH vs miRNA RT-qPCR detection.

American journal of clinical pathology - 1 Apr 2012

Smonskey Matthew T, Block AnneMarie W, Deeb George, Chanan-Khan Asher A, Bernstein Zale P, Miller Kena C, Wallace Paul K, Starostik Petr

Abstract excerpt

Deletion of 13q14.3 (del(13q)) is the most common cytogenetic abnormality in chronic lymphocytic leukemia (CLL) and implies a favorable prognosis. We explored the feasibility of detecting del(13q) by real-time quantitative polymerase chain reaction (PCR) for miR-15a and miR-16-1, whose loci are located in the deleted region. We analyzed 23 cases of B-CLL with monoallelic (10 cases) or biallelic del(13q) (5 cases)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Chromosome Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosome Disorders

Share to Chromosomes, Human, Pair 13

Share to In Situ Hybridization, Fluorescence

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to MicroRNAs

Share to Real-Time Polymerase Chain Reaction

Source

Identifiers

PMID: 22431542
DOI: 10.1309/AJCPP31FSSRQTTAQ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Monoallelic and biallelic deletions of 13q14.3 in chronic lymphocytic leukemia: FISH vs miRNA RT-qPCR detection.PMID 22431542Read ↗

Integrative genomics analyses reveal molecularly distinct subgroups of B-cell chronic lymphocytic leukemia patients with 13q14 deletion.Semantic proximity Read ↗

A large fraction of trisomy 12, 17p-, and 11q- CLL cases carry unidentified microdeletions of miR-15a/16-1.Semantic proximity Read ↗

MiRNA expression profile of chronic lymphocytic leukemia patients with 13q deletion.Semantic proximity Read ↗

Molecular characterization of chronic lymphocytic leukemia patients with a high number of losses in 13q14.Semantic proximity Read ↗

Integrated genomic profiling of chronic lymphocytic leukemia identifies subtypes of deletion 13q14.Semantic proximity Read ↗

Biallelic deletion 13q14.3 in patients with chronic lymphocytic leukemia: cytogenetic, FISH and clinical studiesSemantic proximity Read ↗

Inside the chronic lymphocytic leukemia cell: miRNA and chromosomal aberrationsSemantic proximity Read ↗

13q14 Deletion size and number of deleted cells both influence prognosis in chronic lymphocytic leukemiaSemantic proximity Read ↗

Frequent deletions and down-regulation of micro- RNA genes <i>miR15</i> and <i>miR16</i> at 13q14 in chronic lymphocytic leukemiaSemantic proximity Read ↗

13q14 Deletion and Its Effect on Prognosis of Chronic Lymphocytic LeukemiaSemantic proximity Read ↗

The prognostic significance of various 13q14 deletions in chronic lymphocytic leukemia.Semantic proximity Read ↗

MicroRNA in chronic lymphocytic leukemia: transitioning from laboratory-based investigation to clinical application.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.