Article
Molecular characterization of chronic lymphocytic leukemia patients with a high number of losses in 13q14.
PloS one - 1 Jan 2012
Rodríguez Ana Eugenia, Hernández Jose Ángel, Benito Rocío, Gutiérrez Norma C, García Juan Luis, Hernández-Sánchez María, Risueño Alberto, Sarasquete M Eugenia, Fermiñán Encarna, Fisac Rosa, de Coca Alfonso García, Martín-Núñez Guillermo, de Las Heras Natalia, Recio Isabel, Gutiérrez Oliver, De Las Rivas Javier, González Marcos, Hernández-Rivas Jesús M
Abstract excerpt
BACKGROUND: Patients with chronic lymphocytic leukemia and 13q deletion as their only FISH abnormality could have a different outcome depending on the number of cells displaying this aberration. Thus, cases with a high number of 13q- cells (13q-H) had both shorter overall survival and time to first therapy. The goal of the study was to analyze the genetic profile of 13q-H patients. DESIGN AND METHODS: A total of...
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