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Article

Genotypic screening of the main opiate-related polymorphisms in a cohort of 139 sickle cell disease patients.

American journal of hematology - 1 May 2012

Joly Philippe, Gagnieu Marie-Claude, Bardel Claire, Francina Alain, Pondarre Corinne, Martin Cyril

Abstract excerpt

Because no frequency data are available for the main opiate-related polymorphisms in sickle-cell disease (SCD) populations, we decided to perform such a genotyping in a cohort of 139 individuals. For pharmacodynamics,the OPRM1 A118G and the COMT G322A single nucleotide polymorphisms (SNPs) were chosen for their negative effects on the m receptors [1,2]. For pharmacokinetics [3], important SNPs for the CYP2D6 gene...

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Topics

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Share to Anemia, Sickle Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Codeine

Share to Glucuronosyltransferase

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Share to Receptors, Opioid, mu

Source

Identifiers

PMID: 22430884
DOI: 10.1002/ajh.23137

Genes

ABCB1
COMT
OPRM1
SCD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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