Article
Progressive photoreceptor degeneration, outer segment dysplasia, and rhodopsin mislocalization in mice with targeted disruption of the retinitis pigmentosa-1 (Rp1) gene.
Proceedings of the National Academy of Sciences of the United States of America - 16 Apr 2002
Gao Jiangang, Cheon Kyeongmi, Nusinowitz Steven, Liu Qin, Bei Di, Atkins Karen, Azimi Asif, Daiger Stephen P, Farber Debora B, Heckenlively John R, Pierce Eric A, Sullivan Lori S, Zuo Jian
Abstract excerpt
Retinitis pigmentosa (RP), a common group of human retinopathic diseases, is characterized by late-onset night blindness, loss of peripheral vision, and diminished or absent electroretinogram (ERG) responses. Mutations in the photoreceptor-specific gene RP1 account for 5-10% of cases of autosomal dominant RP. We generated a mouse model of the RP1 form of RP by targeted disruption of the mouse ortholog (Rp1) of...
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