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Article

Retinal degeneration mutation in Sftpa1tm1Kor/J and Sftpd -/- targeted mice.

PloS one - 1 Jan 2018

Bhatti Faizah, Kung Johannes W, Vieira Frederico

Abstract excerpt

Surfactant proteins are important collectin immune molecules with a wide distribution throughout the body, including the ocular system. Mice with gene deletions for the surfactant protein genes Sftpa1 and Sftpd were observed to have visual impairment and thinning of the outer nuclear layers of the retina. We hypothesized that gene deletion of Sftpa1 and Sftpd (Sftpa1tm1Kor/J and Sftpd-/-) results in early retinal...

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Identifiers

PMID: 29969487
DOI: 10.1371/journal.pone.0199824
PMCID: PMC6029784

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