Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression and Role of p53 in the Retina

14 Mar 2012

Abstract excerpt

Since it was identified in 1979, p53 has been widely studied for its role in tumor suppression. It is mutated in approximately half of all human cancers, leading to aberrant cell growth. In addition to its role as a tumor suppressor, p53 is activated in response to various cell stress signals, including DNA damage and hypoxia. This activation leads to alterations in target gene expression, giving p53 a regulatory...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Ocular Oncology and Treatments
Share to Retinal Development and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22427613
DOI: 10.1167/iovs.11-8909

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression and Role of p53 in the RetinaPMID 22427613Read ↗

Blue Light Damage and p53: Unravelling the Role of p53 in Oxidative-Stress-Induced Retinal ApoptosisSemantic proximity Read ↗

The Inability of the Choroid to Revascularize in Oxygen-Induced Retinopathy Results from Increased p53/miR-Let-7b ActivitySemantic proximity Read ↗

Identification of the novel role of pRB in eye cancer.Semantic proximity Read ↗

Role of p53 in Regulating Radiation ResponsesSemantic proximity Read ↗

The P53 pathway: what questions remain to be explored?Semantic proximity Read ↗

Exploring p53 Isoforms: Unraveling Heterogeneous p53 Tumor Suppressor Functionality in Uveal MelanomaSemantic proximity Read ↗

Blinded by the Light: The Growing Complexity of p53.Semantic proximity Read ↗

A Glance of p53 Functions in Brain Development, Neural Stem Cells, and Brain CancerSemantic proximity Read ↗

Exploring the Role of p53 in Radiosensitivity: A Key Player in Cancer TherapySemantic proximity Read ↗

ER stress and unfolded protein response in ocular health and diseaseSemantic proximity Read ↗

Targeting MDM2 and MDMX in RetinoblastomaSemantic proximity Read ↗

[Tumor suppressor gene p53: mechanisms of action in cell proliferation and death].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.