Article
FGFR3 mutations indicate better survival in invasive upper urinary tract and bladder tumours.
European urology - 1 Mar 2009
van Oers Johanna M M, Zwarthoff Ellen C, Rehman Ishtiaq, Azzouzi Abdel-Rahmene, Cussenot Olivier, Meuth Mark, Hamdy Freddie C, Catto James W F
Abstract excerpt
BACKGROUND: Promoter hypermethylation and microsatellite instability are frequent in tumours of the upper urinary tract (UTT) and infrequent in bladder tumours. FGFR3 mutations are common findings in bladder tumours and are associated with a good prognosis. OBJECTIVE: To investigate the occurrence of FGFR3 mutations in UTT and determine the prognostic effect of these genetic changes. DESIGN, SETTING, AND...
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