Article
FGFR3 overexpression is prognostic of adverse outcome for muscle-invasive bladder carcinoma treated with adjuvant chemotherapy.
Urologic oncology - 1 Jan 2014
Sung Ji-Youn, Sun Jong-Mu, Chang Jeong Byong, Il Seo Seong, Soo Jeon Seong, Moo Lee Hyun, Yong Choi Han, Young Kang So, Choi Yoon-La, Young Kwon Ghee
Abstract excerpt
BACKGROUND: Alterations in fibroblast growth factor receptor 3 (FGFR3) have been implicated in the pathogenesis of urothelial carcinoma. However, its clinicopathological significance has not been clearly established, especially in muscle-invasive bladder cancer (MIBC). OBJECTIVES: The aim of our study was to investigate the mutation and overexpression of FGFR3 in MIBC cases from radical cystectomy and to analyze...
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