Consistent genomic alterations in carcinoma in situ of the urinary bladder confirm the presence of two major pathways in bladder cancer development.

doi:10.1002/ijc.24619

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Article

Consistent genomic alterations in carcinoma in situ of the urinary bladder confirm the presence of two major pathways in bladder cancer development.

International journal of cancer - 1 Nov 2009

Zieger Karsten, Marcussen Niels, Borre Michael, Ørntoft Torben F, Dyrskjøt Lars

Abstract excerpt

Bladder cancer develops through different pathways, provisionally entitled "papillary" and "invasive." Carcinoma in situ (CIS) is thought to be the precursor of invasive bladder cancer. However, little is known about chromosomal alterations of these clinically important lesions, and the relationship between chromosomal alterations and the different pathways. We laser-microdissected 12 CIS and 4 dysplasia samples...

Topics

Carcinoma in Situ
Chromosome Aberrations
Gene Dosage
Gene Expression Profiling
Humans
Loss of Heterozygosity
Mutation
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Receptor, Fibroblast Growth Factor, Type 3
Urinary Bladder Neoplasms

Source

Open in PubMed

Identifiers

PMID: 19637316
DOI: 10.1002/ijc.24619

Genes

FGFR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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