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Article

Polymorphisms of inflammatory and metalloproteinase genes, Helicobacter pylori infection and the risk of oesophageal adenocarcinoma.

British journal of cancer - 26 Feb 2008

Früh M, Zhou W, Zhai R, Su L, Heist R S, Wain J C, Nishioka N S, Lynch T J, Shepherd F A, Christiani D C, Liu G

Abstract excerpt

Helicobacter pylori (HP) infection appears protective against oesophageal adenocarcinoma (EA) risk. Matrix metalloproteinases (MMPs) are released in the presence of HP infection. In MMP2 wild-type individuals, HP was significantly protective of EA risk (adjusted odds ratio: 0.29; 95% confidence interval=0.1-0.7). Matrix metalloproteinases may modulate the EA-HP relationship.

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Source

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Identifiers

PMID: 18253117
DOI: 10.1038/sj.bjc.6604234
PMCID: PMC2259195

Genes

MMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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