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Article

Matrix metalloproteinase 1, 3 and 12 polymorphisms and esophageal adenocarcinoma risk and prognosis.

Carcinogenesis - 1 May 2009

Bradbury Penelope A, Zhai Rihong, Hopkins Jessica, Kulke Matthew H, Heist Rebecca S, Singh Simron, Zhou Wei, Ma Clement, Xu Wei, Asomaning Kofi, Ter-Minassian Monica, Wang Zhaoxi, Su Li, Christiani David C, Liu Geoffrey

Abstract excerpt

The matrix metalloproteinase (MMP) family degrade extracellular matrix and mediate pathways including apoptosis, angiogenesis and immunity. We studied the association between four MMP polymorphisms within three MMP genes and esophageal adenocarcinoma (EA) risk and prognosis. A total of 313 EA cases and 455 age and gender frequency-matched controls were genotyped for MMP1 1G/2G, MMP3 6A/5A, MMP12 -82A/G and MMP12...

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Identifiers

PMID: 19321798
DOI: 10.1093/carcin/bgp065
PMCID: PMC2675656

Genes

MMP3
MMP1
MMP12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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