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Article

Evidence for impaired t cell dna methylation in systemic lupus erythematosus and rheumatoid arthritis

1 Nov 1990

Abstract excerpt

Procainamide and hydralazine inhibit T cell DNA methylation and induce autoreactivity in cloned CD4+ T cells. These drugs also induce an autoimmune syndrome, suggesting a possible relationship between DNA hypomethylation, T cell autoreactivity, and certain autoimmune diseases. To test this relationship, DNA methylation was studied in T cells from patients with rheumatoid arthritis and patients with systemic lupus...

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Share to Immune Cell Function and Interaction
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Identifiers

PMID: 2242063
DOI: 10.1002/art.1780331109

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