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Article

Epigenetic regulation of cytokine expression in systemic lupus erythematosus with special focus on T cells

24 Apr 2014

Abstract excerpt

Epigenetic events play a central role in the priming, differentiation and subset determination of T lymphocytes. Through their influence on chromatin conformation and DNA-accessibility to transcription factors and RNA polymerases, epigenetic marks allow or prevent gene expression and control cellular functions including cytokine expression. CpG-DNA methylation and post-translational modifications to histone tails...

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PMID: 24762298
DOI: 10.3109/08916934.2013.801462

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