Article
Phenotypic and functional similarities between 5-azacytidine-treated T cells and a T cell subset in patients with active systemic lupus erythematosus.
Arthritis and rheumatism - 1 Jun 1992
Richardson B C, Strahler J R, Pivirotto T S, Quddus J, Bayliss G E, Gross L A, O'Rourke K S, Powers D, Hanash S M, Johnson M A
Abstract excerpt
OBJECTIVE: Antigen-specific CD4+ T cells treated with DNA methylation inhibitors become autoreactive, suggesting a novel mechanism for autoimmunity. To test whether this mechanism might be involved in systemic lupus erythematosus (SLE), phenotypic markers for the autoreactive cells were sought. METHODS: Cloned normal T cells were treated with the DNA methylation inhibitor 5-azacytidine (5-azaC) and studied for...
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