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Hepatic stellate cells limit hepatocellular carcinoma progression through the orphan receptor endosialin

3 Apr 2017

Abstract excerpt

Hepatocellular carcinoma (HCC) is among the most common and deadliest cancers worldwide. A major contributor to HCC progression is the cross talk between tumor cells and the surrounding stroma including activated hepatic stellate cells (HSC). Activation of HSC during liver damage leads to upregulation of the orphan receptor endosialin (CD248), which contributes to regulating the balance of liver regeneration and...

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PMID: 28373218
DOI: 10.15252/emmm.201607222

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