Article
Mapping gene-environment interactions at regulatory polymorphisms: insights into mechanisms of phenotypic variation.
Transcription - 1 Jan 2000
Maranville Joseph C, Luca Francesca, Stephens Matthew, Di Rienzo Anna
Abstract excerpt
Genetic effects on gene regulation make a substantial contribution to phenotypic diversity, yet their mechanisms remain elusive. Here, we discuss the potential insights to be gained from mapping gene-environment interactions at regulatory polymorphisms (i.e., genetic variation that affects gene expression under specific environmental conditions). We highlight a novel statistical method to identify specific...
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