Article
Modularity and interactions in the genetics of gene expression.
Proceedings of the National Academy of Sciences of the United States of America - 21 Apr 2009
Litvin Oren, Causton Helen C, Chen Bo-Juen, Pe'er Dana
Abstract excerpt
Understanding the effect of genetic sequence variation on phenotype is a major challenge that lies at the heart of genetics. We developed GOLPH (GenOmic Linkage to PHenotype), a statistical method to identify genetic interactions, and used it to characterize the landscape of genetic interactions between gene expression quantitative trait loci. Our results reveal that allele-specific interactions, in which a gene...
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