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Article

Nonlinear regulation enhances the phenotypic expression of trans-acting genetic polymorphisms.

BMC systems biology - 25 Jul 2007

Gjuvsland Arne B, Hayes Ben J, Meuwissen Theo H E, Plahte Erik, Omholt Stig W

Abstract excerpt

BACKGROUND: Genetic variation explains a considerable part of observed phenotypic variation in gene expression networks. This variation has been shown to be located both locally (cis) and distally (trans) to the genes being measured. Here we explore to which degree the phenotypic manifestation of local and distant polymorphisms is a dynamic feature of regulatory design. RESULTS: By combining mathematical models...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17651484
DOI: 10.1186/1752-0509-1-32
PMCID: PMC1994684

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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