A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.

doi:10.1038/ng.649

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.

Nature genetics - 1 Sept 2010

Abnet Christian C, Freedman Neal D, Hu Nan, Wang Zhaoming, Yu Kai, Shu Xiao-Ou, Yuan Jian-Min, Zheng Wei, Dawsey Sanford M, Dong Linda M, Lee Maxwell P, Ding Ti, Qiao You-Lin, Gao Yu-Tang, Koh Woon-Puay, Xiang Yong-Bing, Tang Ze-Zhong, Fan Jin-Hu, Wang Chaoyu, Wheeler William, Gail Mitchell H, Yeager Meredith, Yuenger Jeff, Hutchinson Amy, Jacobs Kevin B, Giffen Carol A, Burdett Laurie, Fraumeni Joseph F, Tucker Margaret A, Chow Wong-Ho, Goldstein Alisa M, Chanock Stephen J, Taylor Philip R

Abstract excerpt

We conducted a genome-wide association study of gastric cancer and esophageal squamous cell carcinoma (ESCC) in ethnic Chinese subjects in which we genotyped 551,152 SNPs. We report a combined analysis of 2,240 gastric cancer cases, 2,115 ESCC cases and 3,302 controls drawn from five studies. In logistic regression models adjusted for age, sex and study, multiple variants at 10q23 had genome-wide significance for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Squamous Cell

Share to Chromosomes, Human, Pair 10

Share to Esophageal Neoplasms

Share to Genetic Loci

Share to Linkage Disequilibrium

Share to Phosphoinositide Phospholipase C

Share to Stomach Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 20729852
DOI: 10.1038/ng.649
PMCID: PMC2947317

Genes

PLCE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.PMID 20729852Read ↗

Esophageal squamous cell carcinoma and gastric cardia adenocarcinoma shared susceptibility locus in PLCE1: a meta-analysis.Semantic proximity Read ↗

Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54.Semantic proximity Read ↗

Novel functional variants locus in PLCE1 and susceptibility to esophageal squamous cell carcinoma: based on published genome-wide association studies in a central Chinese population.Semantic proximity Read ↗

Two novel polymorphisms in PLCE1 are associated with the susceptibility to esophageal squamous cell carcinoma in Chinese population.Semantic proximity Read ↗

Putatively functional PLCE1 variants and susceptibility to esophageal squamous cell carcinoma (ESCC): a case-control study in eastern Chinese populations.Semantic proximity Read ↗

Novel functional variants locus in PLCE1 and susceptibility to digestive tract cancer in the Chinese population: a meta-analysis.Semantic proximity Read ↗

Common genetic variants at 1q22 and 10q23 and gastric cancer susceptibility in a Korean population.Semantic proximity Read ↗

Potentially functional variants of PLCE1 identified by GWASs contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population.Semantic proximity Read ↗

PLCE1 rs2274223 polymorphism contributes to risk of esophageal cancer: evidence based on a meta-analysis.Semantic proximity Read ↗

Gastric cancer may share genetic predisposition with esophageal squamous cell carcinoma in Chinese populations.Semantic proximity Read ↗

Replication study of PLCE1 and C20orf54 polymorphism and risk of esophageal cancer in a Chinese population.Semantic proximity Read ↗

PLCE1 polymorphism and upper gastrointestinal cancer risk: a meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.