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Inhibitory effect of capsule on natural transformation of Streptococcus pneumoniae

28 Aug 2025

Abstract excerpt

ABSTRACT The capsule of Streptococcus pneumoniae ( Spn ) is highly heterogeneous based on the expression of distinct polysaccharides. Spn transformation, controlled by the Com regulon, has been predominantly studied using unencapsulated laboratory strains. However, genomic studies revealed different rates of recombination events in clinical isolates of different serotypes. As these isolates were genetically...

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PMID: 40874614
DOI: 10.1128/mbio.01394-25

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