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Article

Molecular Evolution of the Ankyrin Gene Family

9 Nov 2005

Abstract excerpt

Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Human mutations of ankyrin genes lead to severe genetic diseases such as fatal cardiac arrhythmias and hereditary spherocytosis. To elucidate the evolutionary history of ankyrins, we have identified novel ankyrin sequences in insect, fish, frog, chicken, dog, and...

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PMID: 16280541
DOI: 10.1093/molbev/msj056

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