Article
Type I phosphatidylinositol 4-phosphate 5-kinase homo- and heterodimerization determines its membrane localization and activity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2015
Lacalle Rosa Ana, de Karam Juan C, Martínez-Muñoz Laura, Artetxe Ibai, Peregil Rosa M, Sot Jesús, Rojas Ana M, Goñi Félix M, Mellado Mario, Mañes Santos
Abstract excerpt
Type I phosphatidylinositol 4-phosphate 5-kinases (PIP5KIs; α, β, and γ) are a family of isoenzymes that produce phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] using phosphatidylinositol 4-phosphate as substrate. Their structural homology with the class II lipid kinases [type II phosphatidylinositol 5-phosphate 4-kinase (PIP4KII)] suggests that PIP5KI dimerizes, although this has not been formally...
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