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Article

Mineralocorticoid receptor Iso/Val (rs5522) genotype moderates the association between previous childhood emotional neglect and amygdala reactivity.

The American journal of psychiatry - 1 May 2012

Bogdan Ryan, Williamson Douglas E, Hariri Ahmad R

Abstract excerpt

OBJECTIVE: The amygdala is especially reactive to threatening stimuli, and the degree of reactivity predicts individual differences in the expression of depression and anxiety. Emerging research suggests that emotional neglect during childhood as well as hypercortisolemia may lead to heightened threat-related amygdala reactivity. This raises the possibility that genetic variation affecting...

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Identifiers

PMID: 22407082
DOI: 10.1176/appi.ajp.2011.11060855
PMCID: PMC4700829

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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