Article
Variation in the glucocorticoid receptor gene at rs41423247 moderates the effect of prenatal maternal psychological symptoms on child cortisol reactivity and behavior.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2012
Velders Fleur P, Dieleman Gwen, Cents Rolieke A M, Bakermans-Kranenburg Marian J, Jaddoe Vincent W V, Hofman Albert, Van Ijzendoorn Marinus H, Verhulst Frank C, Tiemeier Henning
Abstract excerpt
Prenatal maternal psychopathology affects child development, but some children seem more vulnerable than others. Genetic variance in hypothalamic-pituitary-adrenal axis genes may influence the effect of prenatal maternal psychological symptoms on child emotional and behavioral problems. This hypothesis was tested in the Generation R Study, a population-based cohort from fetal life onward. In total, 1727 children...
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