Article
Proteomic analysis of plasma from a Tau transgenic mouse.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience - 1 Jun 2012
Kim Yoon-Ha, Lee Eun-Kyung, Park Seung-Ah, Kim Nam-Hee, Kim Chan-Wha
Abstract excerpt
The neurofibrillary tangles (NFTs) formed by the accumulation of abnormal tau filaments have been shown to be involved in Alzheimer's disease (AD) brain degeneration. In this study, a tau transgenic mouse (pNSE/htau23) model was used to monitor changes in protein levels and to search for novel biomarker candidates suitable for the early diagnosis of AD before onset of clinical symptoms. Plasma samples from...
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