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Translational study of Alzheimer's disease (AD) biomarkers from brain tissues in AβPP/PS1 mice and serum of AD patients.

Journal of Alzheimer's disease : JAD - 1 Jan 2015

Sun Yingni, Rong Xianfang, Lu Wenwen, Peng Ying, Li Jiang, Xu Shaofeng, Wang Ling, Wang Xiaoliang

Abstract excerpt

The aim of this study was to investigate potential biomarkers of Alzheimer's disease (AD). Changes in protein expression in brain tissues from AβPP/PS1 transgenic mice were evaluated using two-dimensional gel electrophoresis combined with LC-MS/MS. A total of 23 differentially expressed proteins were successfully identified in brain tissues of which 11 were validated by western blot. Then, the levels of these...

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PMID: 25502766
DOI: 10.3233/JAD-142805

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VDAC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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