Article
Molecular genetic overlap in bipolar disorder, schizophrenia, and major depressive disorder.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Apr 2014
Schulze Thomas G, Akula Nirmala, Breuer René, Steele Jo, Nalls Michael A, Singleton Andrew B, Degenhardt Franziska A, Nöthen Markus M, Cichon Sven, Rietschel Marcella, McMahon Francis J
Abstract excerpt
OBJECTIVES: Genome-wide association studies (GWAS) in complex phenotypes, including psychiatric disorders, have yielded many replicated findings, yet individual markers account for only a small fraction of the inherited differences in risk. We tested the performance of polygenic models in discriminating between cases and healthy controls and among cases with distinct psychiatric diagnoses. METHODS: GWAS results...
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