Article
Identification of a novel locus for triglyceride on chromosome 1p31-32 in families with premature CAD and MI.
Journal of lipid research - 1 May 2008
Seidelmann Sara Bretschger, Li Lin, Shen Gong-Qing, Topol Eric J, Wang Qing Kenneth
Abstract excerpt
An increased plasma triglyceride (TG) level is associated with coronary artery disease (CAD) and myocardial infarction (MI) and is a key characteristic of the metabolic syndrome. Here, we used a genome-wide linkage scan to identify a novel genetic locus that influences the plasma TG level. We genotyped 714 persons in 388 multiplex Caucasian families with premature CAD and MI with 408 polymorphic microsatellite...
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