Article
A comprehensive investigation of variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/R2), and their association with serum adiponectin, type 2 diabetes, insulin resistance and the metabolic syndrome.
BMC medical genetics - 25 Jan 2013
Peters Kirsten E, Beilby John, Cadby Gemma, Warrington Nicole M, Bruce David G, Davis Wendy A, Davis Timothy Me, Wiltshire Steven, Knuiman Matthew, McQuillan Brendan M, Palmer Lyle J, Thompson Peter L, Hung Joseph
Abstract excerpt
BACKGROUND: Low levels of serum adiponectin have been linked to central obesity, insulin resistance, metabolic syndrome, and type 2 diabetes. Variants in ADIPOQ, the gene encoding adiponectin, have been shown to influence serum adiponectin concentration, and along with variants in the adiponectin receptors (ADIPOR1 and ADIPOR2) have been implicated in metabolic syndrome and type 2 diabetes. This study aimed to...
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