Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apolipoprotein e genotype-dependent paradoxical short-term effects of (56)fe irradiation on the brain.

International journal of radiation oncology, biology, physics - 1 Nov 2012

Haley Gwendolen E, Villasana Laura, Dayger Catherine, Davis Matthew J, Raber Jacob

Abstract excerpt

PURPOSE: In humans, apolipoprotein E (apoE) is encoded by three major alleles (ε2, ε3, and ε4) and, compared to apoE3, apoE4 increases the risk of developing Alzheimer disease and cognitive impairments following various environmental challenges. Exposure to irradiation, including that of (56)Fe, during space missions poses a significant risk to the central nervous system, and apoE isoform might modulate this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein E2
Share to Apolipoprotein E3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dentate Gyrus

Share to Ethidium

Share to Fluorescent Dyes

Share to Maze Learning

Share to Memory Disorders

Share to Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 22401921
DOI: 10.1016/j.ijrobp.2011.12.049
PMCID: PMC3742074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apolipoprotein e genotype-dependent paradoxical short-term effects of (56)fe irradiation on the brain.PMID 22401921Read ↗

Genotype differences in anxiety and fear learning and memory of WT and ApoE4 mice associated with enhanced generation of hippocampal reactive oxygen species.Semantic proximity Read ↗

Hippocampal neurogenesis and neuroinflammation after cranial irradiation with (56)Fe particles.Semantic proximity Read ↗

Long-Term Sex- and Genotype-Specific Effects of 56Fe Irradiation on Wild-Type and APPswe/PS1dE9 Transgenic Mice.Semantic proximity Read ↗

Low-dose exposure to malathion and radiation culminates in the dysregulation of multiple neuronal processes instigating neurotoxicity and activation of neurodegeneration pathways in mice hippocampusSemantic proximity Read ↗

Impact of APOE Genotype on Neurocognition Following Conformal Whole Brain Radiotherapy for Brain Metastases: A Post hoc Analysis of Phase II Randomized TrialSemantic proximity Read ↗

Long-term exposure to ELF-MF ameliorates cognitive deficits and attenuates tau hyperphosphorylation in 3xTg AD mice.Semantic proximity Read ↗

Folate and vitamin E deficiency impair cognitive performance in mice subjected to oxidative stress: differential impact on normal mice and mice lacking apolipoprotein E.Semantic proximity Read ↗

Differential susceptibity of transgenic mice lacking one or both apolipoprotein alleles to folate and vitamin E deprivation.Semantic proximity Read ↗

Exercise-induced DNA damage response and memory formation in miceSemantic proximity Read ↗

Treatment by Low-Dose Brain Radiation Therapy Improves Memory Performances without Changes of the Amyloid Load in the TgF344-AD Rat Model.Semantic proximity Read ↗

High-Energy, Whole-Body Proton Irradiation Differentially Alters Long-Term Brain Pathology and Behavior Dependent on Sex and Alzheimer's Disease Mutations.Semantic proximity Read ↗

BDNF augmentation reverses cranial radiation therapy-induced cognitive decline and neurodegenerative consequencesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.