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Article

Long-Term Sex- and Genotype-Specific Effects of 56Fe Irradiation on Wild-Type and APPswe/PS1dE9 Transgenic Mice.

International journal of molecular sciences - 10 Dec 2021

Schroeder Maren K, Liu Bin, Hinshaw Robert G, Park Mi-Ae, Wang Shuyan, Dubey Shipra, Liu Grace Geyu, Shi Qiaoqiao, Holton Peter, Reiser Vladimir, Jones Paul A, Trigg William, Di Carli Marcelo F, Caldarone Barbara J, Williams Jacqueline P, O'Banion M Kerry, Lemere Cynthia A

Abstract excerpt

Space radiation presents a substantial threat to travel beyond Earth. Relatively low doses of high-energy particle radiation cause physiological and behavioral impairments in rodents and may pose risks to human spaceflight. There is evidence that 56Fe irradiation, a significant component of space radiation, may be more harmful to males than to females and worsen Alzheimer's disease pathology in genetically...

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Identifiers

PMID: 34948098
DOI: 10.3390/ijms222413305
PMCID: PMC8703695

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