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Article

Integrated genome-wide pathway association analysis with INTERSNP.

Human heredity - 1 Jan 2012

Herold Christine, Mattheisen Manuel, Lacour André, Vaitsiakhovich Tatsiana, Angisch Marina, Drichel Dmitriy, Becker Tim

Abstract excerpt

OBJECTIVES: Pathway association analysis (PAA) tests for an excess of moderately significant SNPs in genes from a common pathway. METHODS: We present a Monte-Carlo simulation framework that allows to formulate the main ideas of existing PAA approaches using a self-contained rather than a competitive null hypothesis. A stand-alone implementation in INTERSNP makes time-consuming communication with standard GWAS...

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PMID: 22399020
DOI: 10.1159/000336196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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